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Interventional Psychiatry: How NeuroStar TMS and SPRAVATO® Are Changing Depression Care at Greenbrook
Greenbrook offers NeuroStar TMS and SPRAVATO® for treatment-resistant depression.
Curious about NeuroStar TMS or SPRAVATO® for your depression? In this video, Dr. Geoffrey Grammer, Chief Medical Officer, discusses what interventional psychiatry is, how TMS therapy and SPRAVATO® work differently than traditional antidepressants, and why Greenbrook's mission is to make these treatments available to the patients who need them most.
Key Takeaways:
- Treatment-resistant depression is common. According to Dr. Grammer, about one in three people with depression have treatment-resistant depression, meaning medications alone haven’t brought adequate relief.1
- Interventional psychiatry is a new approach that expands depression treatment options outside of traditional antidepressants
- Greenbrook Mental Wellness Centers has over 90 locations across the U.S. and offers two treatment options: NeuroStar TMS therapy and SPRAVATO® (esketamine) nasal spray.
What is Interventional Psychiatry?
Approximately one in three people with major depressive disorder (MDD), do not get adequate relief from antidepressants or talk therapy.1 This is commonly referred to as treatment-resistant depression. This means that millions of Americans can get caught in a discouraging cycle: try a new medication, waiting weeks to see if it works, experience side effects of the medication, and then start all over when it doesn't bring enough relief.1
Interventional psychiatry is a growing area of mental health care that goes beyond medication and talk therapy. It is a specialized procedural subspecialty of psychiatry that utilizes advanced neuromodulation techniques and rapid-acting pharmacological therapies.
"The world of psychiatry is undergoing a major paradigm shift with something we call interventional psychiatry." - Dr. Geoffrey Grammer
If you have tried several medications without feeling better, that doesn't mean that you are out of options. It may mean that you need a treatment with a different mechanism of action such as NeuroStar TMS or SPRAVATO®.
What is NeuroStar TMS?
NeuroStar TMS (transcranial magnetic stimulation) is an FDA-cleared, non-drug treatment that targets the underactive areas of the brain by using focused magnetic pulses. These targeted magnetic pulses help to reignite dormant synapses in the brain and help your brain function the way it was meant to.2,3
In a real-world study, 83% of patient experienced meaningful symptom improvement, and 62% achieved remission, meaning their depression effectively went away.4
What is SPRAVATO®?
SPRAVATO® is an FDA-approved nasal spray treatment for adults who have not found relief with traditional antidepressants. It is indicated for two conditions: treatment resistant depression and major depressive disorder with acute suicidal ideation or behavior in conjunction with an oral antidepressant.
SPRAVATO® works differently from traditional antidepressants. Instead of primarily targeting serotonin or norepinephrine, it modulates glutamate neurotransmission, a mechanism linked to increased synaptic connectivity and neuroplasticity.
Greenbrook's Mission: Making More Treatment Options Accessible
Depression can feel isolating. Especially when multiple medications or therapies haven’t worked. But you are not alone. There are other options for treating treatment-resistant depression.
If you or someone you care about is living with depression that hasn’t improved with traditional treatments, it may be helpful to learn more about NeuroStar TMS and SPRAVATO®.
"Of all the things I've ever done, TMS and SPRAVATO® have been the most rewarding for me," Dr. Grammer says. "I do this because I genuinely enjoy helping people."
Taking the first step toward exploring new treatment options may open the door to new possibilities for managing depression.
References:
- McIntyre, R.S., et al. (2023). Treatment-resistant depression: Definition, prevalence, detection, management, and investigational interventions. World Psychiatry, 22(3), 394-412.
- Post A, et al. (2001). J Psychiatric Research, 35:193-215.
- Liston C, Chen AC, Zebley BD, et al. (2014). Biol Psychiatry, 75(7);517-526.
- Sackeim HA, et al. (2020). Clinical Outcomes in a Large Registry of Patients with Major Depressive Disorder Treated with Transcranial Magnetic Stimulation. J Affective Disorders, 277(12):65-74.
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