What's the Relationship between Depression and Appetite?

Medically reviewed on 11/17/2020 by
Dr. Geoffrey Grammer
Chief Medical Officer

If you've noticed yourself losing or gaining weight while experiencing depression, you're not alone. It's not uncommon for depression to cause changes to appetite, along with a host of other physical symptoms like fatigue and digestive problems. In fact, nearly half of adults with depression experience the combined effects of depression and loss of appetite. Meanwhile, roughly 35 percent see an increased appetite related to depression and may find themselves eating more than normal.



This divergence means that the relationship between depression and appetite is a complex one. Here's a closer look at why depression might change how hungry you feel and where to look for support and treatment.

How Depression May Affect Your Eating Habits 

There's limited research into exactly why depression leads to appetite changes. However, one study using functional magnetic resonance imaging showed that similar parts of the brain are implicated in both depression and appetite cues. Different brain responses are associated with different changes in appetite, which could indicate that there are different subgroups of depression.


Beyond affecting your hunger levels, depression can influence the types of food you eat. It's common for people who are experiencing depression and feeling unmotivated to opt for quick and convenient meals or snacks. Similarly, the fatigue and lack of energy that often come with depression can make it difficult to feel like preparing and cooking healthy meals from scratch. If you have an increased appetite, you may crave comforting prepared foods. These are often high in sugar and addictive. As well as being an easy option, these foods may give you an initial feel-good buzz, boosting your mood and energy in the short term. However, they can also lead to energy slumps later, making you feel worse in the long run.

Healthy Eating and Depression 

It's easy to see how depression and appetite changes can lead to a cycle of under- or overeating and reliance on convenient foods. We all know about the importance of eating a healthy, balanced diet to maintain your overall health and well-being. This is equally true when it comes to depression. Research shows a link between high-sugar diets and reduced mood. In fact, 95 percent of the mood-boosting chemical serotonin is produced in your gastrointestinal tract. What you put into your stomach really can make a difference to what happens inside your brain.



However, when you're experiencing depression, it can be difficult to muster the energy required to take control of your eating habits. This isn't your fault; remember that appetite changes are common with depression. But that doesn't mean you have to put up with them. Even if you're able to make some adjustments on your own, it's important to seek professional treatment for depression. This can set you on the path toward getting your appetite and diet back in balance as well as improving your mental health.

Thanks for subscribing to our list!

Seeking Treatment 

Your first port of call will often be your doctor or health care team. They can listen to your concerns and recommend common first-line treatments such as antidepressant medications or talk therapy, which may help ease your symptoms. But we know that for some people, depression can be more persistent, and certain treatments may not be as effective for everyone. One study showed that even after trying two different medications, a third of people weren't free of depression symptoms. If previous treatments haven't helped you, Transcranial Magnetic Stimulation (TMS) therapy is a non-drug, non-invasive option to consider.



TMS is an FDA-cleared treatment for Major Depressive Disorder (MDD). It works by stimulating areas of the brain involved in mood regulation, so it could help to get both your mental health and your appetite back on track. To learn more about TMS and whether it might be right for you, schedule a no-cost consultation.

Let's see if we might be a good fit

Take our short quiz to see if TMS therapy or nasal esketamine could be right for you

Take the quiz

Share this post

We're Better Together

Subscribe for mental health, self-care, and TMS therapy and nasal esketamine updates for those affected by treatment-resistant depression or OCD.

Contact Us

By providing your email address, you are consenting to receive blog updates from Greenbrook TMS Inc. You may unsubscribe from these alerts at any time by following the “unsubscribe” link at the bottom of email alerts. At Greenbrook TMS Inc. we take the privacy and security of your personal information seriously. To learn more about how we protect your personal information, please refer to our Privacy Policy.

You might also like

September 4, 2025
Watch Kimberly's inspiring journey as she shares how Greenbrook's Care Team and NeuroStar TMS helped her reclaim her life.
August 25, 2025
Andrew's Breakthrough in Treating Depression That Didn't Respond to Medication
By Caroline Wing August 15, 2025
At just 20 years old, Chloe found herself struggling with depression—a challenge that made everyday life feel overwhelming and joy hard to find. Working as a Behavioral Health Technician at Greenbrook Mental Wellness Centers, she had witnessed firsthand how NeuroStar® TMS therapy helped patients improve. It was that experience that ultimately led her to seek treatment for herself. Chloe's decision marked a turning point. She responded remarkably well to NeuroStar® TMS, echoing the very outcomes she used to celebrate in others. What followed was a transformation not only in her mental health but in her overall experience of young adulthood. The Care Team at Greenbrook played an essential role in her recovery. Chloe described the Care Team as “absolutely amazing,” noting their kindness and commitment to checking in regularly. Their support made the treatment process feel less clinical and more personal—a space of trust and comfort she looked forward to each day. As treatment progressed, the changes in Chloe’s life began to blossom. She found herself embracing experiences she once would’ve dismissed. One particular moment that stands out is a pottery class she took with a friend—except this wasn’t just any pottery class. It included cuddling baby goats and lambs while painting.
July 11, 2025
Kelly’s Journey as a Senior Behavioral Health Technician at Greenbrook Mental Wellness Centers